\n | 1st cycle<\/td>\n | 5 or 6<\/td>\n | 10 ECTS<\/td>\n | English<\/td>\n | \/<\/td>\n | \/<\/td>\n | \/<\/td>\n | 30h<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n L: Lectures \u2022 EC: Exercise classes \u2022 LC: Laboratory classes \u2022 T: Tutorial<\/p>\n<\/div> Course learning goals and description<\/h3>Science is not only lab work, it\u2019s also how you will communicate on your results. Come and face the problem of the Writer\u2019s block with the help of an ESTBB school tutor.<\/em><\/p>A specific topic is selected by the student jointly with a school tutor. Student will therefore provide three different types of scientific communication on this topic:<\/p> - a scientific article-review on the topic for scientist<\/li>\n\n
- a press article for all audience<\/li>\n\n
- a poster<\/li><\/ul>
Prerequisite<\/h4>\/<\/p> Evaluation<\/h3>Written productions and poster presentation<\/p><\/balise><\/div> EL-IN2: Research Project<\/h2>\n <\/p>\n\n \n \n \n \n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n <\/tr>\n <\/thead>\n \n | \n \n | Cycle<\/td>\n | Semester<\/td>\n | Credits<\/td>\n | Language<\/td>\n | L<\/td>\n | EC<\/td>\n | LC<\/td>\n | T<\/td>\n <\/tr>\n | \n | 1st cycle<\/td>\n | 5 or 6<\/td>\n | 5 to 10 ECTS<\/td>\n | English<\/td>\n | \/<\/td>\n | \/<\/td>\n | \/<\/td>\n | 30h<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n L: Lectures \u2022 EC: Exercise classes \u2022 LC: Laboratory classes \u2022 T: Tutorial<\/p>\n<\/div> Course learning goals and description<\/h3>Wet lab work can only be learned in a lab! Join one of our Researcher in his\/her struggle to decipher a specific scientific question.<\/em><\/p>Be careful, number of positions is limited to the number of Researchers capable to follow your progress. It is variable from one year to another.<\/em><\/p>During this module, student will have the opportunity to perform a research project from the literature studies, preparation of the experimentation, to the bench work and analyses of the results.<\/p> Project, individual study plan, timeline and objectives will be discussed with the supervisor.<\/p> Prerequisite<\/h3>\/<\/p> Evaluation<\/h3>Written report and final oral presentation<\/p><\/balise><\/div> EL-IN3: Epigenetics<\/h2>\n <\/p>\n\n \n \n \n \n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n <\/tr>\n <\/thead>\n \n | \n \n | Cycle<\/td>\n | Semester<\/td>\n | Credits<\/td>\n | Language<\/td>\n | L<\/td>\n | EC<\/td>\n | LC<\/td>\n | T<\/td>\n <\/tr>\n | \n | 1st cycle<\/td>\n | 5 or 6<\/td>\n | 5 ECTS<\/td>\n | English<\/td>\n | \/<\/td>\n | \/<\/td>\n | \/<\/td>\n | 30h<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n L: Lectures \u2022 EC: Exercise classes \u2022 LC: Laboratory classes \u2022 T: Tutorial<\/p>\n<\/div> Course learning goals and description<\/h3>.<\/p> Learn at your own pace with this online class the fascinating field of Epigenetics, because nothing is written in stone and environment is shaping your genome.<\/em><\/p>The objectives of the course are:<\/p> -To understand what is epigenetics, the different components and mechanisms of the epigenome: chromatin organization, histone modifications, DNA methylation, polycomb repression and non-coding RNAs. <\/p> -To acquire knowledge in Epigenetic regulation during normal development and also the implication of an epigenetic dysregulation in a variety of diseases including cancer and behavioral diseases.<\/p> -To learn what tools and technologies are performed to decode the epigenome.<\/p> -To be introduced to CRISPR mediated epigenome editing and its potential applications.<\/p> Prerequisite<\/h3>Genetic engineering 1, genetics<\/p> Evaluation<\/h3>Moodle tests at the end of each classes and coursework<\/p><\/balise><\/div> EL-IN4: Ecology<\/h2>\n <\/p>\n\n \n \n \n \n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n <\/tr>\n <\/thead>\n \n | \n \n | Cycle<\/td>\n | Semester<\/td>\n | Credits<\/td>\n | Language<\/td>\n | L<\/td>\n | EC<\/td>\n | LC<\/td>\n | T<\/td>\n <\/tr>\n | \n | 1st cycle<\/td>\n | 5 or 6<\/td>\n | 5 ECTS<\/td>\n | English<\/td>\n | \/<\/td>\n | \/<\/td>\n | \/<\/td>\n | 30h<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n L: Lectures \u2022 EC: Exercise classes \u2022 LC: Laboratory classes \u2022 T: Tutorial<\/p>\n<\/div> Course learning goals and description<\/h3>It is first essential to understand our world before becoming a positive actor to face environmental crisis.<\/em><\/p>At the end of this course, the student will be able to understand and analyze the ecological issues of the 21st century.<\/p> The student will be introduced to ecological theory, follow a presentation and analysis of mathematical models and sampling strategy in ecology.<\/p> A large number of examples will be proposed to better understand:<\/p> -the interface between biodiversity and public health and veterinary issues;<\/p> -relations between the environmental crisis of the 21st century and human and animal health<\/p> Prerequisite<\/h3>\/<\/p> Evaluation<\/h3>Moodle tests at the end of each classes and coursework<\/p><\/balise><\/div> EL-IN5: Genome Editing and engineering<\/h2>\n <\/p>\n\n \n \n \n \n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n <\/tr>\n <\/thead>\n \n | \n \n | Cycle<\/td>\n | Semester<\/td>\n | Credits<\/td>\n | Language<\/td>\n | L<\/td>\n | EC<\/td>\n | LC<\/td>\n | T<\/td>\n <\/tr>\n | \n | 1st cycle<\/td>\n | 5 or 6<\/td>\n | 5 ECTS<\/td>\n | English<\/td>\n | \/<\/td>\n | \/<\/td>\n | \/<\/td>\n | 30h<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n L: Lectures \u2022 EC: Exercise classes \u2022 LC: Laboratory classes \u2022 T: Tutorial<\/p>\n<\/div> Course learning goals and description<\/h3>Let\u2019s talk about an extremely hot topic: how to modify a genome?<\/em><\/p>The goal of this course is to introduce students to genome editing and engineering. Different examples will be used to illustrate: 1\/ why, editing a genome is never done without a clear and ethical objective(s), and 2\/ how, the molecular biology tools to do it properly. From random transgene insertion, to a specific genetically modified mouse model, to the famous genome editing tools (ZFN, TALEN and of course CRIPR\/Cas), the major ways to produce a genetically modified organism will be discussed.<\/p> Prerequisite<\/h3>Basis in Genetic and Molecular biology<\/p> Evaluation<\/h3>Moodle tests at the end of each classes and coursework<\/p><\/balise><\/div> EL-IN6: Cancer Biology<\/h2>\n <\/p>\n\n \n \n \n \n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n <\/tr>\n <\/thead>\n \n | \n \n | Cycle<\/td>\n | Semester<\/td>\n | Credits<\/td>\n | Language<\/td>\n | L<\/td>\n | EC<\/td>\n | LC<\/td>\n | T<\/td>\n <\/tr>\n | \n | 1st cycle<\/td>\n | 5 or 6<\/td>\n | 5 ECTS<\/td>\n | English<\/td>\n | \/<\/td>\n | \/<\/td>\n | \/<\/td>\n | 30h<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n L: Lectures \u2022 EC: Exercise classes \u2022 LC: Laboratory classes \u2022 T: Tutorial<\/p>\n<\/div> Course learning goals and description<\/h3>Cancer is a leading cause of death worldwide. Therefore, understanding complex mechanisms leading to cancer, and knowing how this problem might be addressed are keys knowledge if you want to be involved in this fight.<\/em><\/p>Student should be able at the end of this online class:<\/p> -to define Cancer: classification, origin and identification<\/p> -to understand biology behind cancer apparition and development<\/p> -to describe the role of the guardian of the genome: TP53, and determine the consequences of TP53 \u201closs\u201d or mutation<\/p> -to learn about new ways to diagnose Cancer: their advantages but also their limits<\/p> Prerequisite<\/h3>Basis in Genetic and Molecular biology<\/p> Evaluation<\/h3>Moodle tests at the end of each classes and coursework<\/p><\/balise><\/div> AIS5IN1: Cell culture level 2<\/h2>\n <\/p>\n\n \n \n \n \n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n <\/tr>\n <\/thead>\n \n | \n \n | Cycle<\/td>\n | Semester<\/td>\n | Credits<\/td>\n | Language<\/td>\n | L<\/td>\n | EC<\/td>\n | LC<\/td>\n | T<\/td>\n <\/tr>\n | \n | 1st cycle<\/td>\n | 5<\/td>\n | 10 ECTS<\/td>\n | English<\/td>\n | 2h<\/td>\n | \/<\/td>\n | 43h<\/td>\n | \/<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n L: Lectures \u2022 EC: Exercise classes \u2022 LC: Laboratory classes \u2022 T: Tutorial<\/p>\n<\/div> Course learning goal <\/h3>You want to know how to perform cell culture and use it as a model in Research? Come, and join our Assistant Engineer students into this journey! In group of maximum 12 students, you will work with one French student: he\/she will learn from you, and you will learn from him\/her.<\/em><\/p>In this practical, students will work in pair during 4 weeks in a situation close to a real-work environment. They will be asked to follow detailed protocols, to refer to it and organize their work accordingly.<\/p> In these 4 weeks practical, they will learn:<\/p> -how to maintain two mouse embryonic fibroblasts cell lines (divide them, count them, freeze and thaw them).<\/p> -how to do a gene reporter assay: prepare a plasmid (pRGCdeltaFosLacZ), transfect cell lines with the plasmid, and induce the transfected gene. The reporter gene under the specific promoter being LacZ, its activity will be detected by looking at beta-galactosidase activity.<\/p> -how to follow the effect of a treatment on the protein level (tumor suppressor protein p53 being our protein of interest during this practical) : cell treatment, protein extraction and check of the protein level by Western blotting.<\/p> In parallel to technical lab skills, they will learn:<\/p> -to prepare their experiment before the pratical session<\/p> -to work collectively under strict Good Cell Culture and Good Lab Practices (GCCP and GLP) rules<\/p> -the principle of each techniques used<\/p> -to critically analyze their results<\/p> -to write a report as a scientific communication<\/p> Prerequisite<\/h3>Cell biology, basic knowledge in molecular biology<\/p> Evaluation<\/h3>Coursework, written report, test on Moodle<\/p><\/balise><\/div> SVHS5UE01-IN: Applied Immunology<\/h2>\n <\/p>\n\n \n \n \n \n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n <\/tr>\n <\/thead>\n \n | \n \n | Cycle<\/td>\n | Semester<\/td>\n | Credits<\/td>\n | Language<\/td>\n | L<\/td>\n | EC<\/td>\n | LC<\/td>\n | T<\/td>\n <\/tr>\n | \n | 1st cycle<\/td>\n | 5<\/td>\n | 5 ECTS<\/td>\n | English<\/td>\n | 28h<\/td>\n | 12h<\/td>\n | 8h<\/td>\n | \/<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n L: Lectures \u2022 EC: Exercise classes \u2022 LC: Laboratory classes \u2022 T: Tutorial<\/p>\n<\/div> Course learning goal <\/h3>At the end of this course, student will:<\/p> -Know how to describe the different immune responses depending on the pathogen.<\/p> -Know how to describe the mechanisms involved in the development of lymphocytes.<\/p> -Know how to describe the involvement of the immune system in the development of various pathologies.<\/p> -Discover the treatments and therapies used to treat or prevent these pathologies.<\/p> Prerequisite <\/h3>Cell biology, Immunology 1<\/p> Evaluation <\/h3>Written exams and coursework<\/p><\/balise><\/div> SVHS5UE01bis-IN: Ecology<\/h2>\n <\/p>\n\n \n \n \n \n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n <\/tr>\n <\/thead>\n \n | \n \n | Cycle<\/td>\n | Semester<\/td>\n | Credits<\/td>\n | Language<\/td>\n | L<\/td>\n | EC<\/td>\n | LC<\/td>\n | T<\/td>\n <\/tr>\n | \n | 1st cycle<\/td>\n | 5<\/td>\n | 5 ECTS<\/td>\n | English<\/td>\n | 30h<\/td>\n | 12h<\/td>\n | 8h<\/td>\n | \/<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n L: Lectures \u2022 EC: Exercise classes \u2022 LC: Laboratory classes \u2022 T: Tutorial<\/p>\n<\/div> Course learning goal <\/h3>At the end of this course, the student will be able to understand and analyze the ecological issues of the 21st century.<\/p> The student will be introduced to ecological theory, follow a presentation and analysis of mathematical models and sampling strategy in ecology. A large number of examples will be proposed to better understand:<\/p> -the interface between biodiversity and public health and veterinary issues; <\/p> -relations between the environmental crisis of the 21st century and human and animal health<\/p> Prerequisite <\/h3>\/<\/p> Evaluation <\/h3>Written exams and coursework<\/p><\/balise><\/div> SVHS5UE02-IN: System Biology<\/h2>\n <\/p>\n\n \n \n \n \n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n <\/tr>\n <\/thead>\n \n | \n \n | Cycle<\/td>\n | Semester<\/td>\n | Credits<\/td>\n | Language<\/td>\n | L<\/td>\n | EC<\/td>\n | LC<\/td>\n | T<\/td>\n <\/tr>\n | \n | 1st cycle<\/td>\n | 5<\/td>\n | 5 ECTS<\/td>\n | English<\/td>\n | 30h<\/td>\n | 8h<\/td>\n | \/<\/td>\n | 12h<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n L: Lectures \u2022 EC: Exercise classes \u2022 LC: Laboratory classes \u2022 T: Tutorial<\/p>\n<\/div> Course learning goal <\/h3>Systems biology is both a scientific field and a relatively recent paradigm which consists in studying organisms as a whole. It can be approached by a scientific approach since it concerns the study of the interactions between the components of biological systems and their action in the function and behavior of this system. It can also be approached by a philosophical approach because it represents a \"holistic\" approach opposed to the \"reductionism\" used for a long time in life sciences. Following this module will allow the student to place the scientific knowledge acquired since the beginning of his schooling in a complex context, to approach their analysis in a global way by mathematical methods and to have access to a new way of reasoning in biology. The module will also provide new knowledge regarding several areas of biology. In addition to the classic knowledge checks, group bibliographic work will be required to allow the student to implement what he has learned.<\/p> Prerequisite <\/h3>Biology 1<\/p> Evaluation <\/h3>Written exams and coursework<\/p><\/balise><\/div> INS6ETBS02-IN: Genetic Engineering<\/h2>\n <\/p>\n\n \n \n \n \n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n <\/tr>\n <\/thead>\n \n | \n \n | Cycle<\/td>\n | Semester<\/td>\n | Credits<\/td>\n | Language<\/td>\n | L<\/td>\n | EC<\/td>\n | LC<\/td>\n | T<\/td>\n <\/tr>\n | \n | 1st cycle<\/td>\n | 6<\/td>\n | 5 ECTS<\/td>\n | English<\/td>\n | 10h<\/td>\n | \/<\/td>\n | 24h<\/td>\n | \/<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n L: Lectures \u2022 EC: Exercise classes \u2022 LC: Laboratory classes \u2022 T: Tutorial<\/p>\n<\/div> Course learning goal and description <\/h3>The aim of the course is to provide student with knowledge in the different biotechnological tools to study and modify the genetic material of a living organism.<\/p> Following a specific project, students will be guided to find, and therefore understand, the right Molecular Biology tools to be able to validate or not a hypothesis.<\/p> Laboratory classes:<\/em><\/p>During the practical, students will perform the experiments they discuss during the lecture. From the detection of a specific mutation, to the plasmid construction in order to produce a recombinant DNA useful to study the function of the mutated form of the protein of interest.<\/p> 1: Comparison of different method of DNA quantification<\/p> 2: PCR-RFLP and diagnostic of a point of mutation<\/p> 3: DNA cloning, screening and validation, and plasmid production<\/p> Prerequisite <\/h3>Molecular Biology 1<\/p> Evaluation <\/h3>Written exam and coursework (report, exercises, participation)<\/p><\/balise><\/div> INS6ETBS01-IN: Advanced Immunology<\/h2>\n <\/p>\n\n \n \n \n \n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n <\/tr>\n <\/thead>\n \n | \n \n | Cycle<\/td>\n | Semester<\/td>\n | Credits<\/td>\n | Language<\/td>\n | L<\/td>\n | EC<\/td>\n | LC<\/td>\n | T<\/td>\n <\/tr>\n | \n | 1st cycle<\/td>\n | 6<\/td>\n | 5 ECTS<\/td>\n | English<\/td>\n | 10h<\/td>\n | 8h<\/td>\n | 16h<\/td>\n | \/<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n L: Lectures \u2022 EC: Exercise classes \u2022 LC: Laboratory classes \u2022 T: Tutorial<\/p>\n<\/div> Course learning goal and description <\/h3>The aim of this course is to provide the student current and up-to-date knowledge within areas of cellular and molecular immunology.<\/p> The student will be able to mobilize this theoretical knowledge in immunology to choose immunological methods adapted to the biotech processes, and to optimize biotechnology protocols using immunology tools.<\/p> Keywords: vaccination, recombinant antibodies, autoimmunity and hypersensibility<\/p> Laboratory classes:<\/em><\/p>Test of adjuvants in term of efficacity to stimulate the immune response, using techniques of cell culture, ELISA, and RT-qPCR.<\/p> - Pre-Clinical Evaluation of the Nanoliposomal antiPCSK9 Vaccine in Healthy Non-Human Primates \u2013 adapted from Abbas Momtazi-Borojeni et al., Vaccines, 2021<\/p> - Lipid A analog CRX-527 conjugated to synthetic peptides enhances vaccination efficacy and tumor control \u2013 adapted from Tondini et al., npj vaccines, 2022<\/p> Prerequisite <\/h3>Basic knowledge in immunology (immune responses and antibodies)<\/p> Evaluation <\/h3>Written exam and coursework<\/p><\/balise><\/div> INS6ETBS03-IN: Project: European Biotechnology<\/h2>\n <\/p>\n\n \n \n \n \n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n <\/tr>\n <\/thead>\n \n | \n \n | Cycle<\/td>\n | Semester<\/td>\n | Credits<\/td>\n | Language<\/td>\n | L<\/td>\n | EC<\/td>\n | LC<\/td>\n | T<\/td>\n <\/tr>\n | \n | 1st cycle<\/td>\n | 6<\/td>\n | 5 ECTS<\/td>\n | English<\/td>\n | 10h<\/td>\n | \/<\/td>\n | \/<\/td>\n | 30h<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n L: Lectures \u2022 EC: Exercise classes \u2022 LC: Laboratory classes \u2022 T: Tutorial<\/p>\n<\/div> Course learning goal and description <\/h3>Based on specifications defined by a sponsor, the students will have to carry out, in teams, a study of published research work on major European and governmental orientations, European and specific regulations related to a problem in the context of biotechnologies for a biotech established in a country of the European Union.<\/p> This targeted and in-depth scientific and\/or technological and\/or geopolitical state of the art (advantages, disadvantages, etc.) must allow the sponsor, for example, to:<\/p> \u2013 Validate an R&D orientation;<\/p> \u2013 Have a global vision of the subject (scientific articles, studies, publications, patents or even scientific conferences);<\/p> \u2013 Detect emerging technologies;<\/p> \u2013 Find a solution to a technological obstacle;<\/p> \u2013 Find new alternative tracks.\u2013 Validate an R&D orientation;<\/p> \u2013 Have a global vision on the subject by identifying and critically analyzing relevant scientific articles, studies, publications, patents or scientific conferences;<\/p> \u2013 Detect emerging technologies;<\/p> \u2013 Find a solution to technological limits; \u2013 Find new alternative methods<\/p> Prerequisite <\/h3>\/<\/p> Evaluation <\/h3>Written report as a review and an oral presentation<\/p><\/balise><\/div> INS6ETSTI02-IN: Cell technologies<\/h2>\n <\/p>\n\n \n \n \n \n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n | <\/th>\n <\/tr>\n <\/thead>\n \n | \n \n | Cycle<\/td>\n | Semester<\/td>\n | Credits<\/td>\n | Language<\/td>\n | L<\/td>\n | EC<\/td>\n | LC<\/td>\n | T<\/td>\n <\/tr>\n | \n | 1st cycle<\/td>\n | 6<\/td>\n | 5 ECTS<\/td>\n | English<\/td>\n | 10h<\/td>\n | \/<\/td>\n | 30h<\/td>\n | \/<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n | | | | | | | | | | | | |
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